Diabetes Insipidus
Protocols
Essentials of Diagnosis:
- Inability to concentrate urine.
- Large and dilute urine rarely less than 3 litres daily.
- Excessive thirst and resulting disturbance of sleep.
- Deficiency of ADH secretion.
- Inability of distal tubules and collecting ducts of nephrons to respond to ADH (Nephrogenic diabetes insipidus).
Rx:
- Pitressin(Vasopressin) IM 10-20 units of aqueous solution twice daily
or 5-10 units Pitressin tannate in oil every2 to 3 days.
- Chlorpropamide 250 mg daily.
- Chlorthiazide 500 mg in Vasopressin resistant casesto reduce urine volume.