2.Syphilis

Protocols

Syphilis:Click here for more details

Clinical Features :



1)sore throat.

2)fever.

3)swollen lymph glands.

4)headaches.

5)fatigue.

6)muscle aches.

7)wart-like patches around skin folds or genitals.(Small, painless sore (chancre) on the genitals, anus, or mouth)

8)loss of appetite



  • Investigations: 

    • 1. TPHA (+ve after 6 wks )
    • 2. Venereal disease research laboratory (VDRL) test.
    • The VDRL test checks blood or spinal fluid for an antibody that can be produced in people who have syphilis. 
    • 3. Rapid plasma reagin (RPR) test. The RPR test also finds syphilis antibodies.
    • 4. Rapid immunochromatographic test.

    *** TPHA is positive 6-12 months after completete treatment.


Rx:

Early Syphilis(primary/2ndry/latent):(BASHH guideline alternative regment)


Cap. Doxicap(Dixycycline)(100mg)
  • ১+০+১...14 দিন

OR 

Inj.Ceftron(Ceftriaxone) (500mg)

  • IM daily .....10 days (if no penicilline anaphylaxsis)

OR 

Tab.Zimax(azithromycin) (500mg) 

  • 0+0+1........10 days 

OR 

Tab.Eromycin DS(Erythromycin)(500mg)

  • 0+0+1........14 days 


Late latent ,Cardiovascular & gummatous syphilis:

Cap. Doxicap(Dixycycline)(100mg)
  • 1+০+1......28 days


Neuro-Syphilis (opthalmic/neurological involvement):

Cap. Doxicap(Dixycycline)(100mg)
  • 1+০+1......28 days

OR 

Inj.Ceftron(Ceftriaxone) (2g)

  • IM /IV daily/BD .....10 -14 days (if no penicilline anaphylaxsis)

Early Syphilis in Pregnacy:

Inj.Ceftron(Ceftriaxone) (500mg)

  • IM daily .....10 days (if no penicilline anaphylaxsis)

OR 

Tab.Zimax(azithromycin) (500mg) 

  • 0+0+1........10 days 

OR 

Tab.Eromycin DS(Erythromycin)(500mg)

  • 0+0+1........14 days 

Congenital syphilis : 
  • Procaine penicillin 50,000/kg daily IM 10 days.



Advice:
  • অযাচিত যৌন মিলন করা যাবেনা 
  • যৌন মিলনের সময় কনডম ব্যবহার করবেন