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Ferrous Sulphate + Folic Acid + Zinc:

Brand name: Ferozi(drug int),Zif(square)

Adult Dose
Adults: 1-2 capsule daily.
Child Dose
Renal Dose
Administration
For maximum absorption take on
empty stomach, but may take with or
after meals to minimize GI irritation
indication
Iron, Zinc & Folic acid deficiency
Contraindication
Contraindicated in patients with a known
hypersensitivity to any of the ingredients.
Folic Acid is contraindicated in untreated
cobalamine deficiency.
Side Effects
Generally well tolerated. However, a few allergic
reactions may be seen.
Theraputic Class
Iron Vitamin & Mineral Combined preparation
Pregnency Category
Category: Not Classified
pregnancy_description
Mode of Action
Iron: Essential component in the formation of
hemoglobin; adequate amounts of iron are
necessary for effective erythropoiesis; also
serves as a cofactor of several essential enzymes,
including cytochromes that are involved in electron
transport. Replacement of iron stores found in hemoglobin,
myoglobin, and enzymes; works to transport oxygen via
hemoglobin. Folic acid: Required for nucleoprotein synthesis
and the maintenance of normal erythropoiesis; folic acid is
converted in the liver and plasma to its metabolically active
form, tetrahydrofolic acid, by dihydrofolate reductase;
prevents neural tube defects in women of childbearing
potential and higher doses required during pregnancy.
Zinc: Cofactor in over 100 enzymes; plays a role in DNA
synthesis; supports a healthy immune system; helps
maintain a sense of smell and taste; may assist in
porper function of insulin.
Interaction
Concurrent admin with antacids/H2 antagonists may
reduce absorption of iron. Chloramphenicol may delay
response to iron. Iron may reduce the absorption of levodopa,
methyldopa and penicillamine when given together. Absorption
may be reduced when used with quinolones or tetracyclines.
Pack And Size
Per Unit Price: Tk. 2.93
Package: 100's pack

Carbonyl Iron + Folic Acid + Zinc:

Brand name: Ferozi-cl(Drug int),Zif-cl(square)

Adult Dose
One capsule daily. In more severe cases,
2 capsules a day may be required
Child Dose
Renal Dose
Administration
For maximum absorption take on empty stomach,
but may take with or after meals to minimize
GI irritation
indication
Iron,Folic acid and zinc deficiency during
pregnancy and lactation
Contraindication
This product is contraindicated in patients with a
known hypersensitivity to any of the ingredients.
Side Effects
Iron
>10%
Constipation,Diarrhea,Nausea,Epigastric pain,Dark
stools,Vomiting

Frequency Not Defined
Hemosiderosis (during long-term administration of large amounts),
Urine discoloration,Dental stain by some formulations,Heartburn

Folic acid
Bronchospasm,Erythema,Malaise,Pruritus,Rash,Slight flushing

Zinc
Nausea/vomiting,Gastric irritation,Elevations of serum
alkaline phosphatase,
amylase, and lipase that may return to high normal within 1-2 years
of therapy,Neurologic deterioration
Theraputic Class
Iron Vitamin & Mineral Combined preparation
Pregnency Category
Category: Not Classified
pregnancy_description
Mode of Action
Iron: Essential component in the formation of
hemoglobin; adequate amounts of iron are necessary
for effective erythropoiesis; also serves as a cofactor of
several essential enzymes, including cytochromes that
are involved in electron transport. Replacement of iron
stores found in hemoglobin, myoglobin, and enzymes;
works to transport oxygen via hemoglobin. Folic acid:
Required for nucleoprotein synthesis and the maintenance
of normal erythropoiesis; folic acid is converted in the liver
and plasma to its metabolically active form, tetrahydrofolic
acid, by dihydrofolate reductase; prevents neural tube
defects in women of childbearing potential and higher
doses required during pregnancy. Zinc: Cofactor in over
100 enzymes; plays a role in DNA synthesis; supports a
healthy immune system; helps maintain a sense of smell
and taste; may assist in porper function of insulin.
Interaction
Carbonyl iron: Antacids may decrease the absorption of
carbonyl iron. Folic acid: Antiepileptics, oral contraceptives,
anti-TB drugs, alcohol, aminopterin, methotrexate,
pyrimethamine, trimethoprim and sulphonamides may result
to decrease in serum folate contrations. Decreases serum
phenytoin concentrations.
Pack And Size
Per Unit Price: Tk. 3
Package: 50's Pack

Folic Acid:

Brand name: Folison(jayson)

Adult Dose
Oral
Folate-deficient megaloblastic anaemia
Adult: 5 mg daily for 4 mth, up to 15 mg daily in
malabsorption states. Continued dosing at 5 mg
every 1-7 days may be needed in chronic haemolytic
states, depending on the diet and rate of haemolysis.

Prophylaxis of megaloblastic anaemia in pregnancy
Adult: 0.2-0.5 mg daily.

Prophylaxis of neural tube defect in pregnancy
Adult: 4 or 5 mg daily starting before pregnancy and
continued through the 1st trimester.

As supplement for women of child-bearing potential
Adult: 0.4 mg daily.
Child Dose
Folic Acid Deficiency
Infants: 15 mcg/kg/day or 50 mcg/day

1-10 years: 1 mg/day initially, then 0.1-0.4 mg/day
Renal Dose
Administration
May be taken with or without food.
indication
Anemia, Nutritional supplement, Folic acid deficiency,
Megaloblastic anemia, Neural tube defect
Contraindication
This product is contraindicated in patients with a known
hypersensitivity to any of the ingredients. Folic Acid is
contraindicated in untreated cobalamine deficiency.
Side Effects
Bronchospasm,Erythema,Malaise,Pruritus,Rash,Slight flushing
Theraputic Class
Vitamin-B preparations
Pregnency Category
Category: A
pregnancy_description
Mode of Action
Folic acid: Required for nucleoprotein synthesis and the
maintenance of normal erythropoiesis; folic acid is
converted in the liver and plasma to its metabolically
active form, tetrahydrofolic acid, by dihydrofolate
reductase; prevents neural tube defects in women of
childbearing potential and higher doses required
during pregnancy.
Interaction
Antiepileptics, oral contraceptives, anti-TB drugs,
alcohol, aminopterin, methotrexate, pyrimethamine,
trimethoprim and sulphonamides may result to decrease
in serum folate contrations. Decreases serum phenytoin
concentrations.
Pack And Size
Per Unit Price: Tk. 0.35
Package: 500'pack


Folinic Acid (Calcium folinate):

Brand name: Folita(square)Folicid(Tecnodrug)
Preparation: 5mg tablet,Inj. 10mg/1ml(IM/IV)

Adult Dose
Oral
Antidote for methotrexate toxicity
Adult: 15 mg every 6 hr for 10 doses starting
24 hr after the start of methotrexate infusion.
Continue admin until serum levels of methotrexate
is <0.05 micromolar.
May also be given via IM/IV inj.

Folate-deficient megaloblastic anaemia
Adult: 15 mg daily.

Intravenous
Adjunct to fluorouracil in colorectal cancer
Adult: 200 mg/m2 BSA by slow IV inj over at least 3 min
followed by 370 mg/m2 fluorouracil by IV inj. Treatment is
given for 5 consecutive days and repeated at intervals of 28
days for 2 courses. Subsequently, may repeat at 4-5 wkly
intervals if the patient has recovered completely from the
toxic effects of the prior treatment course.

Intramuscular
Folate-deficient megaloblastic anaemia
Adult: Up to 1 mg/day.
Child Dose
Renal Dose
Administration
indication
Colorectal cancer, Methotrexate toxicity, Megaloblastic anaemia
Contraindication
Hypersensitivity, pernicious anaemia and other megaloblastic
anaemias secondary to vit B12-deficiency, intrathecal
and intraventricular admin.
Side Effects
Allergic sensitisation, rash, pruritus, eythema, urticaria,
nausea, vomiting, pyrexia.
Theraputic Class
Pregnency Category
Category: C
pregnancy_description
Mode of Action
Calcium folinate enters the cells as 5-methyl tetrahydrofolate
and supplies the cofactor blocked by methotrexate.
It stabilises the binding of 5-dUMP and thrymidylate
synthetase, enhances flourouracil activity and neutralises
the effects of folic acid antagonists such as methotrexate
but increases those of 5-fluorouracil.
Interaction
Fluorouracil: Folinic acid may increase the toxicity associated
with fluorouracil if the two are administered together. Some
adverse effects that have occurred, particularly in elderly
patients, include severe enterocolitis, diarrhea, and
dehydration. Sulfamethoxazole-trimethoprim: A potential
drug interaction exists with concomitant use of
sulfamethoxazole-trimethoprim and folinic acid.
Folinic acid has been shown to decrease the
efficacy of sulfamethoxazole-trimethoprim in the
treatment of pneumocystis carinii, a common cause
of pneumonia in AIDs patients
Pack And Size
Per Unit Price: Tk. 9
Package: 30's Pack

Mecobalamin:

Brand name: Neural(healthcare-500mcg tab),

Mecobal(general pharma-500mcg/ml inj)

Adult Dose
Oral
Peripheral neuropathies
Adult: 1500 mcg/day in 3 divided doses.

Parenteral
Peripheral neuropathies
Adult: 500 mcg daily IM/IV 3 times/wk.

Megaloblastic anaemia caused by vitamin
B12 deficiency
Adult: 500 mcg daily IM/IV 3 times/wk.
Maintenance dose: After about 2 mth of therapy,
reduce dose to single admin of 500 mcg every 1-3 mth.
Child Dose
Renal Dose
Administration
May be taken with or without food.
indication
Megaloblastic anaemia, Peripheral neuropathies
Contraindication
Hypersensitivity to any component of this product.
Side Effects
Oral: Anorexia, nausea, vomiting and diarrhoea.
Parenteral: Rash, headache, hot sensation, diaphoresis
and pain/induration at IM inj site.

Potentially Fatal: Anaphylactoid reactions (parenteral).
Theraputic Class
Drugs for Megaloblastic Anemia
Pregnency Category
Category: Not Classified
pregnancy_description
Mode of Action
Mecobalamin is the neurologically active form of
vitamin B12 and occurs as a water-soluble vitamin
in the body. It is a cofactor in the enzyme methionine
synthase, which functions to transfer methyl groups for
the regeneration of methionine from homocysteine. In
anaemia, it increases erythrocyte production by promoting
nucleic acid synthesis in the bone marrow and by promoting
maturation and division of erythrocytes.
Interaction
Decreased GI tract absorption with neomycin, aminosalicylic
acid, H2-blockers and colchicine. Reduced serum concentrations
with oral contraceptives. Reduced effects in anaemia with
parenteral chloramphenicol.
Pack And Size
Per Unit Price: Tk. 4.04
Package: 50's pack


Iron + Folic Acid + Vitamin B + Vitamin C:

BRAND NAME: EPL(Globe)

Adult Dose
One capsule daily. In more severe cases,
2 capsules a day may be required.
Child Dose
Renal Dose
Administration
For maximum absorption take on empty stomach,
but may take with or after meals to minimize GI irritation
indication
Nutritional deficiency in pregnancy & lactation.
Contraindication
Patients with a known hypersensitivity to any of
the ingredients, haemolytic anemia.
Side Effects
Allergic sensitization has been reported following oral
administration. May cause nausea, vomiting,
constipation or diarrhoea.
Theraputic Class
Iron & Vitamin Combined preparations
Pregnency Category
Category: Not Classified
pregnancy_description
Mode of Action
Iron: Essential component in the formation of hemoglobin;
adequate amounts of iron are necessary for effective
erythropoiesis; also serves as a cofactor of several
essential enzymes, including cytochromes that are
involved in electron transport. Replacement of iron
stores found in hemoglobin, myoglobin, and enzymes;
works to transport oxygen via hemoglobin. Folic acid:
Required for nucleoprotein synthesis and the maintenance
of normal erythropoiesis; folic acid is converted in the
liver and plasma to its metabolically active form,
tetrahydrofolic acid, by dihydrofolate reductase;
prevents neural tube defects in women of childbearing
potential and higher doses required during pregnancy.
Vitamin B: Plays a role in the synthesis and maintenance
of coenzyme A. Necessary for lipid metabolism, carbohydrate
metabolism, tissue respiration, glycogenolysis, inhibition of very
low-density lipoprotein (VLDL) synthesis. May increaase chylomicron
triglyceride removal from plasma. Vitamin C is necessary for
collagen formation and tissue repair; plays a role in oxidation/reduction
reactions as well as other metabolic pathways including synthesis of
catecholamines, carnitine, and steroids; also plays a role in conversion
of folic acid to folinic acid.
Interaction
Iron: Antacids may decrease the absorption of carbonyl iron. Folic acid:
Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, aminopterin,
methotrexate, pyrimethamine, trimethoprim and sulphonamides may
result to decrease in serum folate contrations. Decreases serum
phenytoin concentrations. Vit C: Deferroxamine, hormonal contraceptives,
flufenazine, warfarin, elemental iron, salicylates, warfarin, fluphenazine,
disulfiram, mexiletine, vitamin B12.
Pack And Size
Per Unit Price: Tk. 3
Package: 30's pack